Sign in
Back
Copy number variation and susceptibility to complex traits
Journal article   Open access  Peer reviewed

Copy number variation and susceptibility to complex traits

Cesar P Canales and Katherina Walz
EMBO molecular medicine, Vol.3(1), pp.1-4
2011-01
DOI: https://doi.org/10.1002/emmm.201000111
PMCID: PMC3401997
PMID: 21204264

Abstract

Genetic Predisposition to Disease Humans Genotype Gene Dosage Transcription Factors - genetics DNA-Binding Proteins - genetics Myelin Proteins - genetics DNA-Binding Proteins - metabolism Proteins - genetics Transcription Factors - metabolism Phenotype Animals Proteins - metabolism Mice Genome, Human Myelin Proteins - metabolism
Copy number variations (CNV) within the genome are extremely abundant. In this closeup, Canales and Walz discuss how CNV are associated with normal variation, genomic disorders, genome evolution, adaptive traits and how the use of a novel screen described by Ermakova et al in this issue that is designed to identify human diseaserelevant phenotypes associated with CNV in the mouse can help elucidating susceptibility or predisposition to diseases loci.
url
https://doi.org/10.1002/emmm.201000111View
Published (Version of record) Open

Metrics

11 Record Views
8 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Citation topics
1 Clinical & Life Sciences
1.186 Chromosome Disorders
1.186.948 Digeorge Syndrome
Web Of Science research areas
Medicine, Research & Experimental
ESI research areas
Clinical Medicine

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: InCites

Details