Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

Lambertus A Kiemeney; Steinunn Thorlacius; Patrick Sulem; Frank Geller; Katja K.H Aben; Simon N Stacey; Julius Gudmundsson; Margret Jakobsdottir; Jon T Bergthorsson; Asgeir Sigurdsson; Thorarinn Blondal; J. Alfred Witjes; Sita H Vermeulen; Christina A Hulsbergen-van de Kaa; Dorine W Swinkels; Martine Ploeg; Erik B Cornel; Henk Vergunst; Thorgeir E Thorgeirsson; Daniel Gudbjartsson; Sigurjon A Gudjonsson; Gudmar Thorleifsson; Kari T Kristinsson; Magali Mouy; Steinunn Snorradottir; Donatella Placidi; Marcello Campagna; Cecilia Arici; Kvetoslava Koppova; Eugene Gurzau; Peter Rudnai; Eliane Kellen; Silvia Polidoro; Simonetta Guarrera; Carlotta Sacerdote; Manuel Sanchez; Berta Saez; Gabriel Valdivia; Charlotta Ryk; Petra de Verdier; Annika Lindblom; Klaus Golka; D. Timothy Bishop; Margaret A Knowles; Sigfus Nikulasson; Vigdis Petursdottir; Eirikur Jonsson; Gudmundur Geirsson; Baldvin Kristjansson; Jose I Mayordomo; Gunnar Steineck; Stefano Porru; Frank Buntinx; Maurice P Zeegers; Tony Fletcher; Rajiv Kumar; Giuseppe Matullo; Paolo Vineis; Anne E Kiltie; Jeffrey R Gulcher; Unnur Thorsteinsdottir; Augustine Kong; Thorunn Rafnar; Kari Stefansson

doi:10.1038/ng.229

Back

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

Journal article

Open access

Peer reviewed

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

Lambertus A Kiemeney, Steinunn Thorlacius, Patrick Sulem, Frank Geller, Katja K.H Aben, Simon N Stacey, Julius Gudmundsson, Margret Jakobsdottir, Jon T Bergthorsson, Asgeir Sigurdsson, …

Nature genetics, Vol.40(11), pp.1307-1312

2008-11

DOI: https://doi.org/10.1038/ng.229

PMCID: PMC4539560

PMID: 18794855

Abstract

We conducted a genome wide SNP association study on 1,803 Urinary Bladder Cancer (UBC) cases and 34,336 controls from Iceland and the Netherlands and follow up studies in seven additional case control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30kb upstream of the c- Myc gene (allele specific OR=1.22; P=9.34×10 −12 ). Approximately 20% of individuals of European ancestry are homozygous for rs9642880 (T) and their estimated risk of developing UBC is 1.49 times that of non-carriers with population attributable risk (PAR) of 17%. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome wide significance, was captured by rs710521 (A) located near the TP63 gene on chromosome 3q28 (allele specific OR=1.19; P=1. 15× 10 −7 ).

Files and links (1)

url

https://doi.org/10.1038/ng.229View

Published (Version of record) Open

Metrics

37 Record Views

331 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.233 Pelvic & Renal Disorders; 1.233.690 Bladder Cancer
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Details

Title: Sequence variant on 8q24 confers susceptibility to urinary bladder cancer
Creators: Lambertus A Kiemeney - Department of Epidemiology & Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
Steinunn Thorlacius - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Patrick Sulem - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Frank Geller - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Katja K.H Aben - Department of Epidemiology & Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
Simon N Stacey - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Julius Gudmundsson - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Margret Jakobsdottir - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Jon T Bergthorsson - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Asgeir Sigurdsson - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Thorarinn Blondal - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
J. Alfred Witjes - Department of Urology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
Sita H Vermeulen - Department of Epidemiology & Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
Christina A Hulsbergen-van de Kaa - Department of Pathology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
Dorine W Swinkels - Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
Martine Ploeg - Department of Urology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
Erik B Cornel - Department of Urology, Streekziekenhuis Midden-Twente, 7550 AM Hengelo, The Netherlands
Henk Vergunst - Department of Urology, Canisius Wilhelmina Ziekenhuis, 6500 GS Nijmegen, The Netherlands
Thorgeir E Thorgeirsson - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Daniel Gudbjartsson - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Sigurjon A Gudjonsson - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Gudmar Thorleifsson - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Kari T Kristinsson - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Magali Mouy - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Steinunn Snorradottir - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Donatella Placidi - Department of Experimental and Applied Medicine - Section of Occupational Medicine and Industrial Hygiene, University of Brescia, 25125 Brescia, Italy
Marcello Campagna - Department of Experimental and Applied Medicine - Section of Occupational Medicine and Industrial Hygiene, University of Brescia, 25125 Brescia, Italy
Cecilia Arici - Department of Experimental and Applied Medicine - Section of Occupational Medicine and Industrial Hygiene, University of Brescia, 25125 Brescia, Italy
Kvetoslava Koppova - State Health Institute, SK-975 56 Banska Bystrica, Slovakia
Eugene Gurzau - Environmental Health Center, 400166 Cluj Napoca j, Romania
Peter Rudnai - National Institute of Environmental Health, H-1450 Budapest, Hungary
Eliane Kellen - Department of General Practice, Catholic University of Leuven, 3000 Leuven, Belgium
Silvia Polidoro - ISI Foundation (Institute for Scientific Interchange), Turin, Italy
Simonetta Guarrera - ISI Foundation (Institute for Scientific Interchange), Turin, Italy
Carlotta Sacerdote - nit of Cancer Epidemiology, University of Turin and Centre for Cancer Epidemiology and Prevention (CPO Piemonte), 10123 Turin, Italy
Manuel Sanchez - Division of Urology. University Hospital, 50009 Zaragoza, Spain
Berta Saez - Health Science Institute. 50009 Zaragoza, Spain
Gabriel Valdivia - Department of Urology. University of Zaragoza School of Medicine. 50009 Zaragoza, Spain
Charlotta Ryk - Dept. Molecular Medicine and Surgery, Karolinska Institutet, S171 76 Stockholm, Sweden
Petra de Verdier - Dept. Molecular Medicine and Surgery, Karolinska Institutet, S171 76 Stockholm, Sweden
Annika Lindblom - Dept. Molecular Medicine and Surgery, Karolinska Institutet, S171 76 Stockholm, Sweden
Klaus Golka - Institute for Occupational Physiology at the University of Dortmund, Dortmund, Germany
D. Timothy Bishop - Section of Epidemiology & Biostatistics, Leeds Institute of Molecular Medicine, St. James’s University Hospital, LS9 7TF Leeds, UK
Margaret A Knowles - Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St. James’s University Hospital, LS9 7TF Leeds, UK
Sigfus Nikulasson - Department of Pathology, Landspitali-University Hospital, 101 Reykjavik, Iceland
Vigdis Petursdottir - Department of Pathology, Landspitali-University Hospital, 101 Reykjavik, Iceland
Eirikur Jonsson - Department of Urology, Landspitali-University Hospital, 101 Reykjavik, Iceland
Gudmundur Geirsson - Department of Urology, Landspitali-University Hospital, 101 Reykjavik, Iceland
Baldvin Kristjansson - Department of Urology, Landspitali-University Hospital, 101 Reykjavik, Iceland
Jose I Mayordomo - Division of Medical Oncology, University Hospital, 50009 Zaragoza, Spain
Gunnar Steineck - Department of Oncology and Pathology, Karolinska Hospital, S171 76 Stockholm, Sweden
Stefano Porru - Department of Experimental and Applied Medicine - Section of Occupational Medicine and Industrial Hygiene, University of Brescia, 25125 Brescia, Italy
Frank Buntinx - Department of General Practice, Catholic University of Leuven, 3000 Leuven, Belgium
Maurice P Zeegers - Unit of Genetic Epidemiology, Department of Public Health and Epidemiology. University of Birmingham, B15 2TT Birmingham, UK
Tony Fletcher - London School of Hygiene & Tropical Medicine, WC1E 7HT London, UK
Rajiv Kumar - Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg D-69120, Germany
Giuseppe Matullo - ISI Foundation (Institute for Scientific Interchange), Turin, Italy
Paolo Vineis - ISI Foundation (Institute for Scientific Interchange), Turin, Italy
Anne E Kiltie - Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St. James’s University Hospital, LS9 7TF Leeds, UK
Jeffrey R Gulcher - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Unnur Thorsteinsdottir - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Augustine Kong - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Thorunn Rafnar - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Kari Stefansson - deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Publication Details: Nature genetics, Vol.40(11), pp.1307-1312
Language: English
Resource Type: Journal article
PMID: 18794855
PMCID: PMC4539560
Record Identifier: 991031561265702976