Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers -- Letter

Journal article

Open access

Peer reviewed

Amaury G Dumont, David G Reynoso and Jonathan C Trent

Cancer research (Chicago, Ill.), Vol.71(6), pp.2403; author reply 2404-2403

2011-03-15

PMID: 21406406

Abstract

Propylene Glycols - pharmacology

Humans

Protein Phosphatase 2 - genetics

Fingolimod Hydrochloride

Enzyme Activation - drug effects

Proto-Oncogene Proteins c-kit - metabolism

Sphingosine - pharmacology

Sphingosine - analogs & derivatives

Animals

Gastrointestinal Stromal Tumors - drug therapy

Gastrointestinal Stromal Tumors - pathology

Protein Phosphatase 2 - metabolism

Cell Line, Tumor

Inhibitory Concentration 50

Proto-Oncogene Proteins c-kit - genetics

Cell Proliferation - drug effects

Mice

Mutation

Gastrointestinal Stromal Tumors - genetics

Immunosuppressive Agents - pharmacology

url

https://doi.org/10.1158/0008-5472.CAN-10-3383View

Published (Version of record) Open

9 Record Views

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Citation topics: 1 Clinical & Life Sciences; 1.118 Soft Tissue, Bone & Nerve Cancers; 1.118.1520 Gastrointestinal Stromal Tumor
Web Of Science research areas: Oncology
ESI research areas: Clinical Medicine

This output has contributed to the advancement of the following goals:

Source: InCites

Title: Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers -- Letter
Creators: Amaury G Dumont
David G Reynoso
Jonathan C Trent
Publication Details: Cancer research (Chicago, Ill.), Vol.71(6), pp.2403; author reply 2404-2403
Publisher: United States
Academic Unit: Miller School of Medicine; UMMG Dept of Medicine - Hematology/Oncology
Language: English
Resource Type: Journal article
PMID: 21406406
Record Identifier: 991031562865502976