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The H1c haplotype at the MAPT locus is associated with Alzheimer's disease
Journal article   Open access  Peer reviewed

The H1c haplotype at the MAPT locus is associated with Alzheimer's disease

A J Myers, M Kaleem, L Marlowe, A M Pittman, A J Lees, H C Fung, J Duckworth, D Leung, A Gibson, C M Morris, …
Human molecular genetics, Vol.14(16), pp.2399-2404
2005-08-15
DOI: https://doi.org/10.1093/hmg/ddi241
PMID: 16000317

Abstract

Humans Genotype Male Phosphoproteins - genetics Nerve Tissue Proteins - genetics tau Proteins Case-Control Studies Haplotypes - genetics Apolipoproteins E - genetics Alleles Aged, 80 and over Female Aged Alzheimer Disease - genetics Supranuclear Palsy, Progressive - genetics
Although it is clear that microtubule associated protein tau (MAPT) is involved in Alzheimer's disease (AD) pathology, it has not been clear whether it is involved genetically. We have recently examined the MAPT locus in progressive supranuclear palsy and found that a haplotype (H1c) on the background of the well-described H1 clade is associated with PSP. Here we report that the same haplotype is associated with the risk of AD in two autopsy confirmed series of cases with ages at death >65 years.
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https://doi.org/10.1093/hmg/ddi241View
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Collaboration types
Domestic collaboration
International collaboration
Citation topics
1 Clinical & Life Sciences
1.52 Neurodegenerative Diseases
1.52.57 Alzheimer's Disease
Web Of Science research areas
Biochemistry & Molecular Biology
Genetics & Heredity
ESI research areas
Molecular Biology & Genetics

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