Abstract
Introduction: Sedentary behavior increases cardiovascular risk due to detrimental effects on blood pressure, vascular function, and glucose metabolism. U.S. Hispanics/Latinos have a high prevalence of sedentary behavior and a large burden of chronic kidney disease (CKD). Therefore, we evaluated the association between sedentary behavior and changes in kidney function over time. Hypothesis: We assessed the hypothesis that higher sedentary time will be associated with increase in proteinuria, decrease in estimated glomerular filtration rate (eGFR), and incident CKD. Methods: We used data from the HCHS/SOL, a community-based cohort of self-identified Hispanic/Latino adults (18-74 years) from diverse backgrounds in the U.S. This study includes 11181 adults who underwent one-week accelerometry at Visit 1 (baseline, 2008-2011) and completed Visit 2 (2014-2017). Linear regression was used to assess the association of sedentary time with change in eGFR and urine albumin- to-creatinine ratio (ACR), and Poisson regression with robust variance was used to estimate the association with rate of incident CKD (defined as the composite of either the development of eGFR <60ml/min/1.73m 2 and a decline in eGFR ≥1 ml/min per year, or ACR ≥30 mg/g), adjusted for covariates and time elapsed between visits. Results: At baseline, mean age was 42.2 years, 51.4% women, mean sedentary time was 11.8 hours, mean eGFR was 106.1mL/min, and median ACR 6.7mg/g. After a median follow-up of 5.9 years, the average decline in eGFR was 0.8ml/min/year and the average change in ACR was 0.3mg/g/year. In fully adjusted models, individuals with higher sedentary time experienced a greater decline eGFR from Visit 1 to Visit 2 (Table 1). Sedentary time was not significantly associated with change in ACR or incident CKD. Conclusion: Sedentary behavior may be associated with a decline in kidney function in U.S. Hispanics/Latinos, which may have important implications for prevention of kidney disease and associated cardiovascular risk in this population.
