Abstract
The skin’s immune surveillance system may also play an important role in the
formation of excessive scar tissue. Langerhans cells, (30) activated T-lymphocytes,
(17) and macrophages (31) have been found in increased number in hypertrophic
scars (21,35,36). Burn patients show a higher level of interleukin-6 expression compared with control patients (32). Keloid patients show antinuclear antibodies from
different immunoglobulin classes against fibroblasts, epithelial, and endothelial cells
as further proof of immunologic involvement. These antibodies were not found in
hypertrophic scars (33,34).