Abstract
Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic syndrome that can cause significant visual loss. It is characterized by diffuse choroidal thickening and hyperpigmentation, multiple melanocytic tumors, exudative retinal detachment, and rapidly progressive cataracts. BDUMP can be the first manifestation of an underlying systemic malignancy in almost half of the cases, and it is most often associated with urogenital cancer in women and lung cancer in men. There is no standardized treatment and follow-up protocol for BDUMP, but the combination of plasmapheresis and treatment of the underlying cancer seems to be the most effective approach.