Abstract
Massive osteoarticular and intercalary allografts used for reconstruction of extremities as well as allografts used for the arthrodesis and stabilization of the spine, filling of bone defects, maxillofacial reconstruction, and the reconstruction of ligaments and tendons of the knee were prepared from 1175 consecutive donors during a 14-year period. Clinical results with these allografts have been encouraging and included over 80% satisfactory results with intercalary and osteoarticular allografts in selected groups of patients, as well as high rates of fusion in the cervical and lumbar spines. A large number of donors allowed for selection of anatomically matched grafts for given recipients. Results with allogeneic grafts supplemented with autologous bone marrow in mandibular reconstructions have been likewise satisfactory. Histological examination of these grafts demonstrated early incorporation, revascularization, resorption of freeze-dried component, and formation of bone ossicle that continued to remodel and form lamellar bone.