Abstract
While relatively rare, primary bone sarcomas are associated with high morbidity and mortality. A comprehensive history, examination, and imaging work-up should be performed in any suspected bone sarcoma. Percutaneous biopsy is preferred to establish a tissue diagnosis. The MSTS system and AJCC system are employed for staging. Osteosarcoma is the most common bone sarcoma, with peaks in the second decade of life and after 59 years. Standard therapy consists of neoadjuvant chemotherapy, wide resection with limb salvage, and adjuvant chemotherapy. Chondrosarcoma is the most common bone sarcoma of adulthood, affecting patients between 40 and 75 years. Wide resection is the mainstay of treatment, as it is relatively resistant to radiation and systemic therapy. Ewing sarcoma is the second most common bone malignancy of childhood, occurring between 5 and 25 years. It is classically associated with a t(11,22) translocation. It is treated with neoadjuvant chemotherapy, wide resection, and adjuvant chemotherapy. Fibrous and vascular sarcomas of the bone are exceedingly rare and treated with wide resection.