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Butyrate and the Colonocyte: Production, Absorption, Metabolism, and Therapeutic Implications
Book chapter

Butyrate and the Colonocyte: Production, Absorption, Metabolism, and Therapeutic Implications

Omaida C Velázquez, Howard M Lederer and John L Rombeau
Dietary Fiber in Health and Disease, pp.123-134
Advances in Experimental Medicine and Biology, Springer US
DOI: https://doi.org/10.1007/978-1-4615-5967-2_14

Abstract

Wheat Bran Volatile Fatty Acid Ulcerative Colitis Proximal Colon Distal Colon
Butyrate is one of the three principal short chain fatty acids (SCFA) in humans generated by colonic microbial fermentation of dietary substrates. SCFA are the C2-5 organic fatty acids, also called the volatile fatty acids (VFA), which include acetate, propionate and butyrate. Colonic intraluminal levels of butyrate may play a role in the pathogenesis of a variety of diseases of the large intestine. This chapter reviews the production, absorption, metabolism, and therapeutic implications of butyrate.

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