Abstract
The predominance of severe SARS-COV-2 infection in men worldwide, in addition to the lower prevalence of infected children, inspired many investigators to study the role of androgens in COVID-19 susceptibility, severity, and mortality. This is supported by recent evidence of modulation of ACE2 and TMPRSS, the receptors by which the SARS-COV-2 virus enters cells, by androgens such as testosterone. Because these receptors are found in male reproductive tissues such as the prostate, it has been hypothesized that there may be an association between the infection and disease of the prostate. This chapter outlines the pathophysiologic connection between the virus and benign and malignant diseases of the prostate as well as changes in management of these conditions during the peak of the pandemic.