Abstract
Completing the tissue engineering triangle of cells, signal, and matrix by using bone marrow aspirate concentrates, recombinant human bone morphogenetic protein-2/acellular collagen sponge, and crushed cancellous mineralized allogeneic bone predictably regenerates large volumes of histologically and functionally useful bone in jaw reconstruction. This composite graft is used directly in the patient's recipient site and is known in situ tissue engineering.