Abstract
Corneal neurotization (CN) is a potentially curative surgical procedure that has revolutionized the management of severe neurotrophic keratopathy (NK). Prior therapies for neurotrophic corneas focused on predominantly supportive measures for ocular surface preservation, but more recent medical and surgical innovations have targeted the underlying corneal hypoesthesia or anesthesia causing inadequate trophic support. Though the modern technique for CN was only first described in 2009, there has been rapid progress in both surgical techniques and understanding of nerve regeneration pathophysiology since the initial report. This has facilitated more widespread adoption of this procedure as a viable treatment for NK even earlier in the disease course to improve ultimate visual rehabilitation outcomes. Given the expansive body of literature that has continued to grow recently, the goal of this chapter is to discuss the current techniques and limitations of this procedure that have arisen over the past decade.