Abstract
The establishment of chromosomal sex (46,XY or
46,XX) is considered the first step in normal sexual
differentiation. However, the first sexual structures
that form may be considered as either primordial or
neutral. The term sex determination refers to the process in which the primordial gonad is committed to
development as testis or ovary. Sex differentiation
refers to the development of the internal accessory
duct structures and external genitalia (1-5).