Abstract
This chapter presents an overview of the two chapters (Chapters 17-18) in Part V of the book. The chapters deal with two case studies, each describing how multidisciplinary teams of investigators working in culturally diverse metropolitan locations, San Francisco (Bay Area) and Miami (Miami–Dade County), set out to confront HIV/ AIDS in two major epicenters of the disease. The institutional similarities and differences in the approaches used to address the HIV/AIDS epidemic are discussed.