HLA Class I/NK Cell Receptor Interaction in Early Human Decidua basalis: Possible Functional Consequences

Magali Rabot; Julie Tabiasco; Beata Polgar; Maryse Aguerre-Girr; Alain Berrebi; Armand Bensussan; Natasa Strbo; Daniel Rukavina; Philippe Le Bouteiller

doi:10.1159/000087914

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HLA Class I/NK Cell Receptor Interaction in Early Human Decidua basalis: Possible Functional Consequences

Book chapter

Peer reviewed

HLA Class I/NK Cell Receptor Interaction in Early Human Decidua basalis: Possible Functional Consequences

Magali Rabot, Julie Tabiasco, Beata Polgar, Maryse Aguerre-Girr, Alain Berrebi, Armand Bensussan, Natasa Strbo, Daniel Rukavina and Philippe Le Bouteiller

Immunology of Pregnancy, pp.72-83

Chemical Immunology and Allergy, S. Karger AG

2005-08

DOI: https://doi.org/10.1159/000087914

PMID: 16129954

Abstract

Chapter

Human decidual NK (dNK) cells differ from their peripheral blood (PB)-NK counterparts. The major subset of PB-NK is CD56dim, CD16+, CD160+ (highly cytolytic), whereas the major subpopulation of dNK is CD56bright, CD16- and CD160- (high cytokine producer). Extravillous cytotrophoblast invading the decidua basalis in early pregnancy expresses the polymorphic HLA-C, and nonpolymorphic HLA-E and HLA-G molecules that can interact with specific HLA class I-dependent dNK receptors, including the immunoglobulin-like KIRs, the lectin-like CD94/NKG2 and the CD160 receptors. There is no clear evidence thus far that dNK cells kill trophoblast cells. Instead they are able to secrete cytokines which are likely to be beneficial for the placental development, maternal uterine spiral arteries remodeling, and the antiviral immune response.

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Title: HLA Class I/NK Cell Receptor Interaction in Early Human Decidua basalis: Possible Functional Consequences
Creators: Magali Rabot - aINSERM U563, Hôpital Purpan and b Department of Obstetrics and Gynecology, Hopital Paule de Viguier, Toulouse, and cFaculté de Médecine de Créteil, INSERM 659, Créteil, France; d Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
Julie Tabiasco - aINSERM U563, Hôpital Purpan and b Department of Obstetrics and Gynecology, Hopital Paule de Viguier, Toulouse, and cFaculté de Médecine de Créteil, INSERM 659, Créteil, France; d Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
Beata Polgar - aINSERM U563, Hôpital Purpan and b Department of Obstetrics and Gynecology, Hopital Paule de Viguier, Toulouse, and cFaculté de Médecine de Créteil, INSERM 659, Créteil, France; d Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
Maryse Aguerre-Girr - aINSERM U563, Hôpital Purpan and b Department of Obstetrics and Gynecology, Hopital Paule de Viguier, Toulouse, and cFaculté de Médecine de Créteil, INSERM 659, Créteil, France; d Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
Alain Berrebi - aINSERM U563, Hôpital Purpan and b Department of Obstetrics and Gynecology, Hopital Paule de Viguier, Toulouse, and cFaculté de Médecine de Créteil, INSERM 659, Créteil, France; d Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
Armand Bensussan - aINSERM U563, Hôpital Purpan and b Department of Obstetrics and Gynecology, Hopital Paule de Viguier, Toulouse, and cFaculté de Médecine de Créteil, INSERM 659, Créteil, France; d Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
Natasa Strbo - aINSERM U563, Hôpital Purpan and b Department of Obstetrics and Gynecology, Hopital Paule de Viguier, Toulouse, and cFaculté de Médecine de Créteil, INSERM 659, Créteil, France; d Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
Daniel Rukavina - aINSERM U563, Hôpital Purpan and b Department of Obstetrics and Gynecology, Hopital Paule de Viguier, Toulouse, and cFaculté de Médecine de Créteil, INSERM 659, Créteil, France; d Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
Philippe Le Bouteiller - aINSERM U563, Hôpital Purpan and b Department of Obstetrics and Gynecology, Hopital Paule de Viguier, Toulouse, and cFaculté de Médecine de Créteil, INSERM 659, Créteil, France; d Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
Contributors: U.R Markert (Editor)
Publication Details: Immunology of Pregnancy, pp.72-83
Series: Chemical Immunology and Allergy
Publisher: S. Karger AG; Basel, Switzerland
Number of pages: 12
ISSN: 1662-2898
Academic Unit: Miller School of Medicine; Microbiology and Immunology Research
Language: English
Resource Type: Book chapter
PMID: 16129954
Record Identifier: 991031597815502976