Abstract
Histopathology is critical at each stage of colorectal cancer. These include histological sub‐typing of colonic polyps for risk assessment in screening population, confirming the diagnosis of invasive carcinoma and providing prognostic indicators for patient outcome and in deciding postoperative therapy options. Histopathology and immunohistochemistry interpretation by a pathologist is important for accurate reporting of the pathological parameters and their effective applications to improve the quality of care for a colorectal cancer patient. This chapter describes histopathology parameters of colon cancer, their clinical relevance, and importance of a pathologist in the multidisciplinary care of a colorectal cancer patient.