Abstract
This chapter presents an interdisciplinary research program in Miami that focused on group-based, cognitive behavioral stress management (CBSM) interventions among HIV-infected individuals. It begins with a brief introduction to the common language that has allowed the research team to share and integrate basic concepts. It then discusses how psychosocial variables that affect quality of life in individuals with HIV can influence the subclinical markers of disease that are associated with disease progression and mortality. This is followed by discussion of the revolution in HIV patient management brought about by combination therapy and the advent of protease inhibitors.