Abstract
Intestinal transplantation is a life‐saving procedure for patients with complicated intestinal failure. Its potential for sustained success is manifest by several patients alive more than 20 years after transplantation who are nutritionally independent, with restored health and social life. Nevertheless, there remains two substantial concerns related to long‐term outcomes of intestinal transplantation: they lag behind those of other solid organ transplants, and are related to a comparatively unrelenting risk of graft loss or mortality due to rejection, disease recurrence or infection. Inclusion of the liver and other components of a multivisceral graft seems to protect the intestine. HLA mismatch, rejection, type of immunosuppression, splenectomy and lack of social support, are risk factors for late graft loss.