Abstract
In the 1950s, hypothermia was induced prior to surgery to assist procedures that caused prolonged ischemia, including heart surgery [1–3] and organ transplants [4]. Within its first decade, hypothermia was applied to emergent medical situations that were characterized by cerebral ischemia and stroke [5, 6] myocardial infarction (MI) [7, 8], and cardiac arrest patients [9, 10]_ENREF_10.