Abstract
Animal studies examining the effects of SSD and AgNO3 on wounds have
showed no significant effect (107) on epithelialization rate. Silver sulfadiazine was
also found to increase the rate of neovascularization. In another study in rats, silver
compounds were found to promote wound healing, reduce the inflammatory and
granulation phases of healing and influence metal ion binding (135). Moreover, Geronemus et al. (105) found increased re-epithelialization rate in domestic pigs with the
use of SSD. However, Leitch et al. (136) found SSD to cause inhibition of wound
contraction in an acute wound rat model. Likewise, Niedner and Schopf (111) found
a slight, nonsignificant reduction of granulation tissue formation with the use of
AgNO3.