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Pathogenesis of Myositis
Book chapter

Pathogenesis of Myositis

Dana P Ascherman
Managing Myositis, pp.267-274
Springer International Publishing
2019-12-15
DOI: https://doi.org/10.1007/978-3-030-15820-0_28

Abstract

Major histocompatibility complex (MHC) Inclusion body myositis (IBM) Tumor necrosis factor (TNF) T cell Cytokine Endoplasmic reticulum stress (ER stress) Innate immunity Interferon (IFN) Adaptive immunity Inflammasome Dermatomyositis (DM) Autophagy Polymyositis (PM) Idiopathic inflammatory myopathy (IIM) B cell B cell activating factor (BAFF) Toll-like receptor (TLR) Nuclear factor kappa-light-chain-enhancer of B cells (NF-κB)
In this overview of pathogenic mechanisms contributing to the development of idiopathic inflammatory myopathy, we highlight the relative contributions of genetic risk, environmental triggering, adaptive immunity, innate immunity, and “nonimmune” signaling pathways that culminate in muscular as well as extra-muscular tissue pathology. Improved understanding of this complex network will enhance our ability to develop novel therapeutic targets.

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