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Prevention of Post-Traumatic Excitotoxic Brain Damage with NMDA Antagonist Drugs: A New Strategy for the Nineties
Book chapter

Prevention of Post-Traumatic Excitotoxic Brain Damage with NMDA Antagonist Drugs: A New Strategy for the Nineties

R Bullock, Y Kuroda, G. M Teasdale and J Mcculloch
Neurotraumatology: Progress and Perspectives, pp.49-55
Acta Neurochirurgica, Springer Vienna
DOI: https://doi.org/10.1007/978-3-7091-9233-7_15

Abstract

Head injury excitotoxicity glutamate brain ischaemia
Excitotoxic mechanisms due to overactivity of the amino acid neurotransmitters glutamate and aspartate maybe responsible for brain damage after injury. In this review we examine ischaemia and shear injury, which are relevant to human head injury. The opportunities for treatment using glutamate antagonist drugs are discussed.

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