Abstract
Arterial hypertension is a leading cause of cardiovascular morbidity and mortality. Although antihypertensive drugs have been shown to reduce cardiovascular events and are widely available, in many patients, blood pressure is not reduced to guideline‐recommended values despite multi‐drug therapy. Because the sympathetic nervous system plays a substantial role in hypertension, device‐based therapies have been introduced to lower blood pressure by modulating nervous system activity. This chapter will review the data behind and technical aspects of one of those technologies: renal denervation (RND).