Sign in
Back
Selectivity and Localization of Anthracyclines in Cardiac-Muscle and Non-Muscle Cells Relevance to Multidrug Resistance
Book chapter

Selectivity and Localization of Anthracyclines in Cardiac-Muscle and Non-Muscle Cells Relevance to Multidrug Resistance

T. J Lampidis, D Kolonias, N Savaraj, M Israel and W Priebe
Analytical Use of Fluorescent Probes in Oncology, pp.425-426
NATO ASI Series, Springer US
DOI: https://doi.org/10.1007/978-1-4615-5845-3_47

Abstract

Cardiac Fibroblast Anthracycline Antibiotic Resistance Ratio Organic Cation Resistant Cell Line
Cardiac-muscle (CM) vs cardiac non-muscle (NM) cells (fibroblasts) have been shown to preferentially accumulate positively-charged anthracyclines (AT) (1), xanthene dyes (2), and other organic cations (3). It was not clear however, how the chemical charge and lipophilicity of AT affected uptake and intracellular localization in these cells which have been further characterized as being pgp multi-drug resistant negative (MDR -) for cardiac-muscle cells and MDR+for cardiac fibroblast.

Metrics

6 Record Views

Details