Abstract
Limbal stem cell deficiency (LSCD) can be due to various causes and leads to corneal scarring and neovascularization as a common phenotypic endpoint. Patients require surgical intervention to manage pain/photophobia and restore vision. Patients should have a healthy donor limbus for an autograft, and the cause of LSCD should be resolved to avoid recurrence. Severe causes leading to LSCD might cause concomitant disease requiring further intervention (like keratoplasty, cataract extraction, pupilloplasty, etc.). Patients should be educated about the risks and benefits of the procedure, including alternatives.