Abstract
Fibrin glues to secure skin grafts were first reported by Tidrick andWarner in 1944
(13). Since then, the use of tissue adhesives in promoting graft take has been described
for split-thickness graft on chronic wounds (14) and burns (15). Even though fibrin glue
on donor sites does not appear to be completely homeostatic (16), they has been shown
to be very effective in reducing blood loss during skin graft anchoring. In a study on 20
patients, Vibe and Pless (17) were able to show a significant enhancement in split skin
graft area take using fibrin glue, especially if grafts were located on difficult-to-graft
body regions, such as on skin folds. Animal studies have shown that fibrin gluemay even
be helpful in reducing scar formation by reducing inflammation and skin graft contraction (18). After grafting, it is important to note that survival is also dependent upon
occlusion of the graft (19). Keeping the graft initially moist and preventing dehydration
provides an optimal environment for graft-wound bed interface.