Trauma, Inflammation, Cochlear Implantation Induced Hearing Loss and Otoprotective Strategies to Limit Hair Cell Death and Hearing Loss

Stefania Goncalves; Enrique Perez; Esperanza Bas; Christine T Dinh; Thomas R Van De Water

doi:10.1007/978-3-319-92507-3_9

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Trauma, Inflammation, Cochlear Implantation Induced Hearing Loss and Otoprotective Strategies to Limit Hair Cell Death and Hearing Loss

Stefania Goncalves, Enrique Perez, Esperanza Bas, Christine T Dinh and Thomas R Van De Water

Inflammatory Mechanisms in Mediating Hearing Loss, pp.165-187

Springer International Publishing

2018-07-19

DOI: https://doi.org/10.1007/978-3-319-92507-3_9

Abstract

Electrode insertion trauma

Foreign body reaction

Pharmacological treatment

Inflammatory process signaling molecules

Cochlear drug delivery

Protective hypothermia

Apoptosis

Hair cells are highly sensitive units that in response to trauma, inflammation, and cochlear implantation activate different signaling pathways leading to hair cell death and hearing impairment. In this chapter we discuss the most recent literature regarding signaling pathways of hair cell loss, mechanisms and inflammatory responses after noise exposure and electrode insertion, and otoprotective strategies that can limit hair cell death and hearing loss.

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Title: Trauma, Inflammation, Cochlear Implantation Induced Hearing Loss and Otoprotective Strategies to Limit Hair Cell Death and Hearing Loss
Creators: Stefania Goncalves - Department of Otolaryngology, University of Miami Ear Institute, University of Miami Miller School of Medicine, Miami, USA
Enrique Perez - Department of Otolaryngology, University of Miami Ear Institute, University of Miami Miller School of Medicine, Miami, USA
Esperanza Bas - Department of Otolaryngology, University of Miami Ear Institute, University of Miami Miller School of Medicine, Miami, USA
Christine T Dinh - Department of Otolaryngology, University of Miami Ear Institute, University of Miami Miller School of Medicine, Miami, USA
Thomas R Van De Water - Department of Otolaryngology, University of Miami Ear Institute, University of Miami Miller School of Medicine, Miami, USA
Publication Details: Inflammatory Mechanisms in Mediating Hearing Loss, pp.165-187
Publisher: Springer International Publishing; Cham
Academic Unit: Miller School of Medicine; UMMG Department of Otolaryngology
Language: English
Resource Type: Book chapter
Record Identifier: 991031600831402976