Abstract
Background:
This study reports our experience with endoscopic endonasal anterior skull base resection for olfactory neuroblastoma.
Study Design:
This study is a retrospective chart review at a tertiary medical center from 1996 to 2013.
Methods:
A total of 22 patients underwent anterior total (
n
= 19) or hemi (
n
= 3) skull base resection for olfactory neuroblastoma. The outcomes measured include demographics, operative details, postoperative course, and oncological outcomes including Kaplan–Meier analysis.
Results:
Mean age was 59.9 years; mean follow-up was 43.3 months (range, 1–203 months). The modified kadish staging at presentation was stage A in six patients, B in nine patients, C in six, and D in one patient. All cases were primary, four patients had major complications including cranial, orbital, or pulmonary embolism and three had minor complications. All patients underwent skull base reconstruction using acellular dermal allograft either as single layer (
n
= 19) or double layer (
n
= 2) or in a combination with a nasoseptal flap (
n
= 1). One patient had a postoperative cerebrospinal fluid leak which required revision skull base reconstruction using a second layer of acellular dermal allograft and lumbar drain placement. One patient had positive final margins and one patient developed local recurrence on long-term follow-up.
Conclusion:
Endoscopic anterior skull base resection for olfactory neuroblastoma and reconstruction using single layer acellular dermal allograft provides good oncological outcomes and low-postoperative morbidity.