Abstract
Magnetoelectric nanoparticles (MENPs) offer a promising avenue for minimally invasive, wireless neural stimulation by transducing time-varying magnetic fields into localized electric fields capable of modulating neural activity. In this work, we assess the effectiveness of MENPs in stimulating retinal neurons using ex-vivo explants from Thyl-GCaMP6f transgenic rats. Our findings show that MENP-treated retinal tissue exhibited distinct calcium transients in response to pulsed magnetic fields ( 20-100 \text{Hz} , up to 100 mT), with the most robust responses consistently observed at 50Hz. No such activity was detected in control samples lacking the piezoelectric component. These results validate the capacity of MENPs to elicit targeted neural activation and support their potential as a non-invasive alternative to conventional retinal prosthetics based on electrodes.