15-gene expression profile and PRAME as an integrated prognostic test for uveal melanoma: First report of Collaborative Ocular Oncology Group Study No. 2 (COOG2.1)

J. William Harbour; Zelia Correa; Amy Schefler; Prithvi Mruthyunjaya; Miguel Materin; Thomas Aaberg; Alison Skalet; David Reichstein; Ezekiel Weis; Ivana Kim; Timothy Fuller; Hakan Demirci; Kisha Piggott; Basil Williams; Eugene Shildkrot; Antonio Capone; Scott Oliver; Scott Walter; John Mason; Devron Char; Michael Altaweel; Jill Wells; Jay Duker; Peter Hovland; Daniel Gombos; Tony Tsai; Cameron Javid; Brian Marr; Ang Gao; Christina Decatur; James Dollar; Stefan Kurtenbach; Song Zhang

doi:10.5061/dryad.n8pk0p340

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15-gene expression profile and PRAME as an integrated prognostic test for uveal melanoma: First report of Collaborative Ocular Oncology Group Study No. 2 (COOG2.1)

J. William Harbour, Zelia Correa, Amy Schefler, Prithvi Mruthyunjaya, Miguel Materin, Thomas Aaberg, Alison Skalet, David Reichstein, Ezekiel Weis, Ivana Kim, …

Dryad

2025-02-26

DOI: https://doi.org/10.5061/dryad.n8pk0p340

Appears in Miller School of Medicine - Latest Publications

Abstract

Cancer Prognosis

Choroidal melanoma

FOS: Clinical medicine

Gene expression profile

Molecular classification

PRAME

Prognostic biomarkers

Progression-free survival

Prospective studies

uveal melanoma

Validated and accurate prognostic testing is critical for precision medicine in uveal melanoma (UM). Our aims were to (1) prospectively validate an integrated prognostic classifier combining a 15-gene expression profile (15-GEP) and PRAME RNA expression, and (2) identify clinical variables that enhance the prognostic accuracy of the 15-GEP/PRAME classifier.

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Title: 15-gene expression profile and PRAME as an integrated prognostic test for uveal melanoma: First report of Collaborative Ocular Oncology Group Study No. 2 (COOG2.1)
Creators: J. William Harbour - The University of Texas Southwestern Medical Center
Zelia Correa - University of Miami
Amy Schefler - Retina Consultants of Texas
Prithvi Mruthyunjaya - Stanford University
Miguel Materin - Duke University
Thomas Aaberg - Retina Specialists of Michigan
Alison Skalet - Oregon Health and Science University Hospital
David Reichstein - Tennessee Retina
Ezekiel Weis - University of Alberta
Ivana Kim - Harvard Medical School
Timothy Fuller - Texas Retina Associates
Hakan Demirci - University of Michigan–Ann Arbor
Kisha Piggott - Washington University in St. Louis
Basil Williams - University of Cincinnati
Eugene Shildkrot - University of Virginia
Antonio Capone - Associated Retina Consultants (Royal Oak, MI)
Scott Oliver - University of Colorado Health
Scott Walter - Helen and Harry Gray Cancer Center
John Mason - University of Alabama
Devron Char - Tumori Foundation
Michael Altaweel - University of Wisconsin Health
Jill Wells - Emory University
Jay Duker - Tufts University
Peter Hovland - Retina Associates
Daniel Gombos - The University of Texas MD Anderson Cancer Center
Tony Tsai - Retinal Consultants Medical Group (Sacramento, CA)
Cameron Javid - Retina Associates
Brian Marr - Columbia University
Ang Gao - The University of Texas Southwestern Medical Center
Christina Decatur - University of Miami
James Dollar - University of Miami
Stefan Kurtenbach - University of Miami
Song Zhang - The University of Texas Southwestern Medical Center
Publisher: Dryad
Grant note: National Eye Institute (https://ror.org/03wkg3b53) National Cancer Institute (https://ror.org/040gcmg81) The University of Texas Southwestern Medical Center (https://ror.org/05byvp690) Research to Prevent Blindness (https://ror.org/04drjs621)
Academic Unit: Miller School of Medicine; UMMG Department of Ophthalmology
Language: English
Resource Type: Dataset
Record Identifier: 991032588709902976