Abstract
This dissertation explores the synthesis, properties, and biomedical applications of magnetoelectric nanoparticles (MENPs) with a focus on their potential in cancer therapy and neurological stimulation. MENPs, characterized by their ability to convert magnetic fields into localized electric fields, offer promising non-invasive alternatives for therapeutic interventions in oncology and neuroscience. The research begins with a detailed examination of the fundamental requirements for MENPs in biomedical applications, including biocompatibility, magnetic properties, and targeted delivery, that need to be addressed. A detailed synthesis method for producing highly efficient MENPs is presented, demonstrating their functionality in theranostic applications, particularly for treating solid tumors like pancreatic cancer.
MENPs, when combined with magnetic fields, have shown potential to induce localized tumor ablation, paving the way for minimally invasive cancer treatments. Furthermore, the particles were found to be effective when used as a tumor specific contrast agent in MRI.
In addition to their cancer applications, MENPs are also investigated for their role in neurological interventions, particularly in stimulating movement in vivo. By acting as nanoelectrodes on neuronal membranes, MENPs can wirelessly control neural activity, offering a breakthrough for brain-machine interfaces (BMIs), neuroprosthetics, and other potential therapeutics. The research highlights the ability of MENPs to induce specific motor responses without the need for implanted electrodes, demonstrating their potential for non-invasive neuromodulation.
The dissertation concludes by discussing future directions, emphasizing the steps required for clinical translation of MENP-based cancer therapies and the further development of MENPs as a brain-machine interface tool. The findings underscore MENPs' transformative potential in modern medicine, offering new paradigms for treating both neurological disorders and cancer.