Abstract
Specific binding of one of the most potent analogs of phencyclidine (PCP), [
3H]PCP-3-OH, in rat brain membranes revealed the labeling of high (K
d = 0.5 nM) and low (K
d = 16 nM) affinity binding sites. (+)SKF 10047 potently inhibited high, but not low, affinity [
3H]PCP-3-OH binding. (+)[
3H]SKF 10047 apparently labeled the high affinity PCP-3-OH binding site and also an additional site, sensitive to haloperidol, which is distinct from the two sites labeled by [
3H]PCP-3-OH.
