A Dominant Role for CD8+-T-Lymphocyte Selection in Simian Immunodeficiency Virus Sequence Variation

David H O'Connor; Adrian B McDermott; Kendall C Krebs; Elizabeth J Dodds; Jacqueline E Miller; Edna J Gonzalez; Timothy J Jacoby; Levi Yant; Helen Piontkivska; Ralph Pantophlet; Dennis R Burton; William M Rehrauer; Nancy Wilson; Austin L Hughes; David I Watkins

doi:10.1128/JVI.78.24.14012-14022.2004

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A Dominant Role for CD8+-T-Lymphocyte Selection in Simian Immunodeficiency Virus Sequence Variation

Journal article

Open access

Peer reviewed

A Dominant Role for CD8+-T-Lymphocyte Selection in Simian Immunodeficiency Virus Sequence Variation

David H O'Connor, Adrian B McDermott, Kendall C Krebs, Elizabeth J Dodds, Jacqueline E Miller, Edna J Gonzalez, Timothy J Jacoby, Levi Yant, Helen Piontkivska, Ralph Pantophlet, …

Journal of virology, Vol.78(24), pp.14012-14022

2004-12

DOI: https://doi.org/10.1128/JVI.78.24.14012-14022.2004

PMCID: PMC533930

PMID: 15564508

Abstract

Pathogenesis and Immunity

CD8 + T lymphocytes (CD8-TL) select viral escape variants in both human immunodeficiency virus and simian immunodeficiency virus (SIV) infections. The frequency of CD8-TL viral escape as well as the contribution of escape to overall virus diversification has not been assessed. We quantified CD8-TL selection in SIV infections by sequencing viral genomes from 35 SIVmac239-infected animals at the time of euthanasia. Here we show that positive selection for sequences encoding 46 known CD8-TL epitopes is comparable to the positive selection observed for the variable loops of env . We also found that >60% of viral variation outside of the viral envelope occurs within recognized CD8-TL epitopes. Therefore, we conclude that CD8-TL selection is the dominant cause of SIV diversification outside of the envelope.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV-1
Web Of Science research areas: Virology
ESI research areas: Microbiology

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Details

Title: A Dominant Role for CD8+-T-Lymphocyte Selection in Simian Immunodeficiency Virus Sequence Variation
Creators: David H O'Connor - Wisconsin Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin
Adrian B McDermott - Wisconsin Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin
Kendall C Krebs - Wisconsin Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin
Elizabeth J Dodds - Wisconsin Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin
Jacqueline E Miller - Wisconsin Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin
Edna J Gonzalez - Wisconsin Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin
Timothy J Jacoby - Wisconsin Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin
Levi Yant - Wisconsin Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin
Helen Piontkivska - Wisconsin Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin
Ralph Pantophlet - Wisconsin Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin
Dennis R Burton - Wisconsin Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin
William M Rehrauer - Wisconsin Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin
Nancy Wilson - Wisconsin Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin
Austin L Hughes - Wisconsin Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin
David I Watkins - Wisconsin Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin
Publication Details: Journal of virology, Vol.78(24), pp.14012-14022
Publisher: American Society for Microbiology
Academic Unit: UMMG Department of Pathology
Language: English
Resource Type: Journal article
PMID: 15564508
PMCID: PMC533930
Record Identifier: 991031600121502976