A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project

Latarsha J Carithers; Kristin Ardlie; Mary Barcus; Philip A Branton; Angela Britton; Stephen A Buia; Carolyn C Compton; David S DeLuca; Joanne Peter-Demchok; Ellen T Gelfand; Ping Guan; Greg E Korzeniewski; Nicole C Lockhart; Chana A Rabiner; Abhi K Rao; Karna L Robinson; Nancy V Roche; Sherilyn J Sawyer; Ayellet V Segrè; Charles E Shive; Anna M Smith; Leslie H Sobin; Anita H Undale; Kimberly M Valentino; Jim Vaught; Taylor R Young; Helen M Moore

doi:10.1089/bio.2015.0032

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A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project

Journal article

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A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project

Latarsha J Carithers, Kristin Ardlie, Mary Barcus, Philip A Branton, Angela Britton, Stephen A Buia, Carolyn C Compton, David S DeLuca, Joanne Peter-Demchok, Ellen T Gelfand, …

Biopreservation and biobanking, Vol.13(5), pp.311-319

2015-10-01

DOI: https://doi.org/10.1089/bio.2015.0032

PMCID: PMC4675181

PMID: 26484571

Abstract

Original Articles

The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund, was established to study the correlation between human genetic variation and tissue-specific gene expression in non-diseased individuals. A significant challenge was the collection of high-quality biospecimens for extensive genomic analyses. Here we describe how a successful infrastructure for biospecimen procurement was developed and implemented by multiple research partners to support the prospective collection, annotation, and distribution of blood, tissues, and cell lines for the GTEx project. Other research projects can follow this model and form beneficial partnerships with rapid autopsy and organ procurement organizations to collect high quality biospecimens and associated clinical data for genomic studies. Biospecimens, clinical and genomic data, and Standard Operating Procedures guiding biospecimen collection for the GTEx project are available to the research community.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.189 Genome Studies; 1.189.455 Genome-Wide Association Studies
Web Of Science research areas: Cell Biology; Chemistry, Applied; Medical Laboratory Technology
ESI research areas: Molecular Biology & Genetics

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Title: A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project
Creators: Latarsha J Carithers - 1Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland
Kristin Ardlie - 2The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Mary Barcus - 3Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc., Frederick, Maryland
Philip A Branton - 1Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland
Angela Britton - 3Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc., Frederick, Maryland
Stephen A Buia - 3Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc., Frederick, Maryland
Carolyn C Compton - 1Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland
David S DeLuca - 2The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Joanne Peter-Demchok - 1Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland
Ellen T Gelfand - 2The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Ping Guan - 1Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland
Greg E Korzeniewski - 3Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc., Frederick, Maryland
Nicole C Lockhart - 1Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland
Chana A Rabiner - 1Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland
Abhi K Rao - 1Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland
Karna L Robinson - 3Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc., Frederick, Maryland
Nancy V Roche - 3Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc., Frederick, Maryland
Sherilyn J Sawyer - 1Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland
Ayellet V Segrè - 2The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Charles E Shive - 3Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc., Frederick, Maryland
Anna M Smith - 3Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc., Frederick, Maryland
Leslie H Sobin - 3Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc., Frederick, Maryland
Anita H Undale - 3Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc., Frederick, Maryland
Kimberly M Valentino - 3Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc., Frederick, Maryland
Jim Vaught - 1Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland
Taylor R Young - 2The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Helen M Moore - 1Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland
Publication Details: Biopreservation and biobanking, Vol.13(5), pp.311-319
Publisher: Mary Ann Liebert, Inc
Language: English
Resource Type: Journal article
PMID: 26484571
PMCID: PMC4675181
Record Identifier: 991031577247402976