A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

Ludmila Prokunina-Olsson; Amanda Black; Dimitrios Trichopoulos; Silvia Selinski; Jarmo Virtamo; Margaret R Karagas; Robert N Hoover; Robert Grubb; Federico Canzian; Nuria Malats; Carlotta Sacerdote; Mariana C Stern; Maria Teresa Landi; Silvia Polidoro; Xifeng Wu; Manuela Gago-Dominguez; Sita H Vermeulen; Jose I Mayordomo; Colin P Dinney; W Ryan Diver; Consol Serra; David Van Den Berg; Giuseppe Matullo; Reina García-Closas; Anne Tjonneland; Jack A Taylor; Monica McGrath; Mark T W Teo; Katja K Aben; Malcolm C Pike; Montserrat Garcia-Closas; Klaus Golka; Neil Caporaso; Nilanjan Chatterjee; Michelle A T Hildebrandt; Anne E Kiltie; Susan M Gapstur; Michael Thun; Kevin B Jacobs; Hushan Yang; José I Sanz-Velez; Stefano Porru; Amy Hutchinson; Salvatore Panico; Alison Johnson; Paolo Vineis; Elio Riboli; Margaret A Knowles; Olivier Cussenot; Soren Besenbacher; Nathaniel Rothman; Bogdan Czerniak; Simone Benhamou; Gerald Andriole; Carmen Navarro; David T Bishop; Thorunn Rafnar; Kvetoslava Koppova; Paul Brennan; Manolis Kogevinas; William Wheeler; Alfredo Carrato; Adonina Tardón; Patrick Sulem; Eric J Jacobs; Eugen Gurzau; Jan G Hengstler; Ashley Godfrey; Rajiv Kumar; Jonine D Figueroa; Stephen J Chanock; J Alfred Witjes; Francoise Clavel-Chapelon; Zhaoming Wang; Meredith Yeager; Jian-Min Yuan; Lambertus A Kiemeney; Dalsu Baris; H Bas Bueno-de-Mesquita; Borje Ljungberg; Demetrius Albanes; Molly Schwenn; Joseph F Fraumeni; María D García-Prats; Alessandra Allione; Geraldine Cancel-Tassin; Zongli Xu; Remco R Makkinje; David J Hunter; Mark P Purdue; Yi-Ping Fu; Sophia C E Bolick; Meng Chen; Gabriel Valdivia; Peter Rudnai; Stephanie J Weinstein; Simonetta Guarrera; Tony Fletcher; Josep Lloreta; Laurie Burdett; Francisco X Real; Alan Schned; Victoria K Cortessis; Holger Dietrich; Kari Stefansson; Debra T Silverman; Immaculata De Vivo; Naomi E Allen; Fulvio Ricceri; Manuel Sanchez

doi:10.1038/ng.687

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A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

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A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

Ludmila Prokunina-Olsson, Amanda Black, Dimitrios Trichopoulos, Silvia Selinski, Jarmo Virtamo, Margaret R Karagas, Robert N Hoover, Robert Grubb, Federico Canzian, Nuria Malats, …

Nature genetics, Vol.42(11), pp.978-984

2010-11

DOI: https://doi.org/10.1038/ng.687

PMCID: PMC3049891

PMID: 20972438

Abstract

We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10−12) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10−11) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10−7) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10−11) and a tag SNP for NAT2 acetylation status (P = 4 × 10−11), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis.

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.233 Pelvic & Renal Disorders; 1.233.690 Bladder Cancer
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics

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Title: A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
Creators: Ludmila Prokunina-Olsson - Division of Cancer Epidemiology and Genetics, National Cancer Institute
Amanda Black - Division of Cancer Epidemiology and Genetics, National Cancer Institute
Dimitrios Trichopoulos - Department of Epidemiology, Harvard School of Public Health Bureau of Epidemiologic Research, Academy of Athens
Silvia Selinski - Leibniz Research Centre for Working Environment and Human Factors
Jarmo Virtamo - National Institute for Health and Welfare
Margaret R Karagas - Dartmouth Medical School
Robert N Hoover - Division of Cancer Epidemiology and Genetics, National Cancer Institute
Robert Grubb - Department of Urology, Washington University School of Medicine
Federico Canzian - Genomic Epidemiology Group, German Cancer Research Center
Nuria Malats - Spanish National Cancer Research Centre
Carlotta Sacerdote - Human Genetics Foundation (HuGeF) Unit of Cancer Epidemiology, University of Torino
Mariana C Stern - Department of Preventive Medicine, Keck School of Medicine, University of Southern California
Maria Teresa Landi - Division of Cancer Epidemiology and Genetics, National Cancer Institute
Silvia Polidoro - Human Genetics Foundation (HuGeF)
Xifeng Wu - Department of Epidemiology, The University of Texas MD Anderson Cancer Center
Manuela Gago-Dominguez - Department of Preventive Medicine, Keck School of Medicine, University of Southern California
Sita H Vermeulen - Department of Epidemiology, Biostatistics and Health Technology Assessment, Radboud University Nijmegen Medical Centre Department of Human Genetics, Radboud University Nijmegen Medical Centre
Jose I Mayordomo - University of Zaragoza
Colin P Dinney - Department of Urology, The University of Texas MD Anderson Cancer Center
W Ryan Diver - Epidemiology Research Program, American Cancer Society
Consol Serra - Universitat Pompeu Fabra
David Van Den Berg - Department of Preventive Medicine, Keck School of Medicine, University of Southern California
Giuseppe Matullo - Department of Genetics, Biology and Biochemistry, University of Torino Human Genetics Foundation (HuGeF)
Reina García-Closas - Unidad de Investigación, Hospital Universitario de Canarias
Anne Tjonneland - Danish Cancer Society, Institute of Cancer Epidemiology
Jack A Taylor - National Institute of Environmental Health Sciences
Monica McGrath - Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health
Mark T W Teo - Leeds Institute of Molecular Medicine, St. James's University Hospital, University of Leeds
Katja K Aben - Department of Epidemiology, Biostatistics and Health Technology Assessment, Radboud University Nijmegen Medical Centre Comprehensive Cancer Center East
Malcolm C Pike - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center
Montserrat Garcia-Closas - Division of Cancer Epidemiology and Genetics, National Cancer Institute
Klaus Golka - Leibniz Research Centre for Working Environment and Human Factors
Neil Caporaso - Division of Cancer Epidemiology and Genetics, National Cancer Institute
Nilanjan Chatterjee - Division of Cancer Epidemiology and Genetics, National Cancer Institute
Michelle A T Hildebrandt - Department of Epidemiology, The University of Texas MD Anderson Cancer Center
Anne E Kiltie - Gray Institute for Radiation Oncology and Biology, University of Oxford
Susan M Gapstur - Epidemiology Research Program, American Cancer Society
Michael Thun - Epidemiology Research Program, American Cancer Society
Kevin B Jacobs - Core Genotype Facility, SAIC-Frederick, Inc., National Cancer Institute-Frederick
Hushan Yang - Department of Epidemiology, The University of Texas MD Anderson Cancer Center
José I Sanz-Velez - San Jorge University Hospital
Stefano Porru - Department of Experimental and Applied Medicine, Section of Occupational Medicine and Industrial Hygiene, University of Brescia
Amy Hutchinson - Core Genotype Facility, SAIC-Frederick, Inc., National Cancer Institute-Frederick
Salvatore Panico - Department of Clinical and Experimental Medicine, Federico II University
Alison Johnson - Vermont Cancer Registry
Paolo Vineis - Human Genetics Foundation (HuGeF) Imperial College London
Elio Riboli - Imperial College London
Margaret A Knowles - Leeds Institute of Molecular Medicine, St. James's University Hospital, University of Leeds
Olivier Cussenot - Department of Urology, Assistance Publique-Hôpitaux de Paris, Tenon Hospital Centre de Recherche sur les Pathologies Prostatiques
Soren Besenbacher - deCODE Genetics
Nathaniel Rothman - Division of Cancer Epidemiology and Genetics, National Cancer Institute
Bogdan Czerniak - Department of Pathology, The University of Texas MD Anderson Cancer Center
Simone Benhamou - Institut national de la santé et de la recherche médicale, U946, Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain (CEPH) Centre National de la Recherche Scientifique, UMR8200, Institut Gustave-Roussy
Gerald Andriole - Department of Urology, Washington University School of Medicine
Carmen Navarro - CIBER Epidemiología y Salud Pública (CIBERESP) Department of Epidemiology, Murcia Regional Health Council
David T Bishop - Leeds Institute of Molecular Medicine, St. James's University Hospital, University of Leeds
Thorunn Rafnar - deCODE Genetics
Kvetoslava Koppova - State Health Institute
Paul Brennan - International Agency for Research on Cancer
Manolis Kogevinas - Centre for Research in Environmental Epidemiology (CREAL) Municipal Institute of Medical Research CIBER Epidemiología y Salud Pública (CIBERESP) National School of Public Health
William Wheeler - Information Management Services, Inc
Alfredo Carrato - Ramón y Cajal University Hospital
Adonina Tardón - CIBER Epidemiología y Salud Pública (CIBERESP) Instituto Universitario de Oncología, Universidad de Oviedo
Patrick Sulem - deCODE Genetics
Eric J Jacobs - Epidemiology Research Program, American Cancer Society
Eugen Gurzau - Babes Bolyai University, Environmental Health Center
Jan G Hengstler - Leibniz Research Centre for Working Environment and Human Factors
Ashley Godfrey - National Institute of Environmental Health Sciences
Rajiv Kumar - Division of Molecular Genetic Epidemiology, German Cancer Research Center
Jonine D Figueroa - Division of Cancer Epidemiology and Genetics, National Cancer Institute
Stephen J Chanock - Division of Cancer Epidemiology and Genetics, National Cancer Institute
J Alfred Witjes - Department of Urology, Radboud University Nijmegen Medical Centre
Francoise Clavel-Chapelon - Centre for Research in Epidemiology and Population Health, Institute Gustave-Roussy, Paris South University
Zhaoming Wang - Core Genotype Facility, SAIC-Frederick, Inc., National Cancer Institute-Frederick
Meredith Yeager - Core Genotype Facility, SAIC-Frederick, Inc., National Cancer Institute-Frederick
Jian-Min Yuan - Masonic Cancer Center, University of Minnesota
Lambertus A Kiemeney - Department of Epidemiology, Biostatistics and Health Technology Assessment, Radboud University Nijmegen Medical Centre Comprehensive Cancer Center East Department of Urology, Radboud University Nijmegen Medical Centre
Dalsu Baris - Division of Cancer Epidemiology and Genetics, National Cancer Institute
H Bas Bueno-de-Mesquita - National Institute for Public Health and the Environment (RIVM)
Borje Ljungberg - Department of Surgical and Perioperative Sciences, University of Umea
Demetrius Albanes - Division of Cancer Epidemiology and Genetics, National Cancer Institute
Molly Schwenn - Maine Cancer Registry
Joseph F Fraumeni - Division of Cancer Epidemiology and Genetics, National Cancer Institute
María D García-Prats - San Jorge University Hospital
Alessandra Allione - Human Genetics Foundation (HuGeF)
Geraldine Cancel-Tassin - Centre de Recherche sur les Pathologies Prostatiques
Zongli Xu - National Institute of Environmental Health Sciences
Remco R Makkinje - Department of Human Genetics, Radboud University Nijmegen Medical Centre
David J Hunter - Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health
Mark P Purdue - Division of Cancer Epidemiology and Genetics, National Cancer Institute
Yi-Ping Fu - Division of Cancer Epidemiology and Genetics, National Cancer Institute
Sophia C E Bolick - National Institute of Environmental Health Sciences
Meng Chen - Department of Epidemiology, The University of Texas MD Anderson Cancer Center
Gabriel Valdivia - University of Zaragoza
Peter Rudnai - National Institute of Environmental Health
Stephanie J Weinstein - Division of Cancer Epidemiology and Genetics, National Cancer Institute
Simonetta Guarrera - Human Genetics Foundation (HuGeF)
Tony Fletcher - Institute of Hygiene and Tropical Medicine
Josep Lloreta - Hospital del Mar-Institut Municipal d'Investigació Mèdica (IMIM), Universitat Pompeu Fabra
Laurie Burdett - Core Genotype Facility, SAIC-Frederick, Inc., National Cancer Institute-Frederick
Francisco X Real - Spanish National Cancer Research Centre Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
Alan Schned - Dartmouth Medical School
Victoria K Cortessis - Department of Preventive Medicine, Keck School of Medicine, University of Southern California
Holger Dietrich - Department of Urology, Paul Gerhardt Foundation
Kari Stefansson - deCODE Genetics Faculty of Medicine, University of Iceland
Debra T Silverman - Division of Cancer Epidemiology and Genetics, National Cancer Institute
Immaculata De Vivo - Channing Laboratory, Department of Medicine, Brigham and Women's Hospital
Naomi E Allen - Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford
Fulvio Ricceri - Department of Genetics, Biology and Biochemistry, University of Torino Human Genetics Foundation (HuGeF)
Manuel Sanchez - University of Zaragoza
Publication Details: Nature genetics, Vol.42(11), pp.978-984
Language: English
Resource Type: Journal article
PMID: 20972438
PMCID: PMC3049891
Record Identifier: 991031559978902976