A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3

D.V Ivanov; T.V Tyazhelova; L Lemonnier; N Kononenko; A.A Pestova; E.A Nikitin; N Prevarskaya; R Skryma; Y.V Panchin; N.K Yankovsky; A.V Baranova

doi:10.1016/S0014-5793(03)00211-4

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A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3

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A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3

D.V Ivanov, T.V Tyazhelova, L Lemonnier, N Kononenko, A.A Pestova, E.A Nikitin, N Prevarskaya, R Skryma, Y.V Panchin, N.K Yankovsky, …

FEBS letters, Vol.539(1), pp.156-160

2003

DOI: https://doi.org/10.1016/S0014-5793(03)00211-4

PMID: 12650944

Abstract

13q14.3

B-cell chronic lymphocytic leukemia

K + channel regulating protein

Prostate cancer

Tumor suppressor gene

We report the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3. This gene includes three exons and has two alternatively spliced isoforms that are expressed in normal tissues and in some tumor cell lines. Protein KCNRG has high homology to tetramerization domain of voltage-gated K + channels. Using the patch-clamp technique we determined that KCNRG suppresses K + channel activity in human prostate cell line LNCaP. It is known that selective blockers of K + channels suppress lymphocyte and LNCaP cell line proliferation. We suggest that KCNRG is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.79 Molecular & Cell Biology - Physiology; 1.79.239 Potassium Channel
Web Of Science research areas: Biochemistry & Molecular Biology; Biophysics; Cell Biology
ESI research areas: Biology & Biochemistry

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Title: A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3
Creators: D.V Ivanov - Vavilov Institute of General Genetics, 3 Gubkina Str., 119991 Moscow, Russia
T.V Tyazhelova - Vavilov Institute of General Genetics, 3 Gubkina Str., 119991 Moscow, Russia
L Lemonnier - Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, Bâtiment SN3, USTL, 59655 Villeneuve d’Ascq, France
N Kononenko - Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, Bâtiment SN3, USTL, 59655 Villeneuve d’Ascq, France
A.A Pestova - Vavilov Institute of General Genetics, 3 Gubkina Str., 119991 Moscow, Russia
E.A Nikitin - Hematology Research Center of Russia, Novozykovski pr.4a, 125167 Moscow, Russia
N Prevarskaya - Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, Bâtiment SN3, USTL, 59655 Villeneuve d’Ascq, France
R Skryma - Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, Bâtiment SN3, USTL, 59655 Villeneuve d’Ascq, France
Y.V Panchin - Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, Bâtiment SN3, USTL, 59655 Villeneuve d’Ascq, France
N.K Yankovsky - Vavilov Institute of General Genetics, 3 Gubkina Str., 119991 Moscow, Russia
A.V Baranova - Vavilov Institute of General Genetics, 3 Gubkina Str., 119991 Moscow, Russia
Publication Details: FEBS letters, Vol.539(1), pp.156-160
Publisher: Elsevier B.V
Academic Unit: Miller School of Medicine; UMMG Department of Ophthalmology
Language: English
Resource Type: Journal article
PMID: 12650944
Record Identifier: 991031562176302976