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A peptide-based synthetic transcription factor selectively down-regulates the proto-oncogene CFOS in tumour cells and inhibits proliferation
Journal article

A peptide-based synthetic transcription factor selectively down-regulates the proto-oncogene CFOS in tumour cells and inhibits proliferation

Madhumita Chakraborty and Siddhartha Roy
Chemical communications (Cambridge, England), Vol.53(2), pp.376-379
2016-12-22
DOI: https://doi.org/10.1039/C6CC08086C
PMID: 27935608

Abstract

Proto-Oncogene Proteins c-fos - chemistry Serum Response Factor - metabolism Humans Serum Response Factor - chemistry Proto-Oncogene Proteins c-fos - metabolism Models, Molecular ets-Domain Protein Elk-1 - chemistry Down-Regulation - drug effects Peptides - pharmacology Peptides - chemical synthesis ets-Domain Protein Elk-1 - metabolism Cell Line, Tumor Protein Conformation Proto-Oncogene Proteins c-fos - genetics Cell Proliferation - drug effects Nucleic Acid Conformation
Selectively regulating genes is an important goal in Chemical Biology. We report the development of a peptide-based synthetic transcription factor which binds the targeted DNA sequence with high affinity and single base-pair discrimination capability. When delivered inside a tumor cell, it regulated targeted genes selectively and inhibited cell proliferation.

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7 Times Cited - Web of Science

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Citation topics
1 Clinical & Life Sciences
1.25 Molecular & Cell Biology - Cancer, Autophagy & Apoptosis
1.25.537 c-Myc
Web Of Science research areas
Chemistry, Multidisciplinary
ESI research areas
Chemistry

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#3 Good Health and Well-Being

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