Sign in
Back
A simple method for estimating association constants between monoclonal antibodies and derivatized or native antigens
Journal article

A simple method for estimating association constants between monoclonal antibodies and derivatized or native antigens

W Schramm, T Yang, M E Meyerhoff and L G Bachas
Clinical chemistry (Baltimore, Md.), Vol.36(7), pp.1360-1363
1990-07
DOI: https://doi.org/10.1093/clinchem/36.7.1360
PMID: 2372952

Abstract

Antibodies, Monoclonal - analysis Antigen-Antibody Complex - analysis Antigens - analysis Binding Sites, Antibody Computer Simulation Models, Biological Progesterone - analogs & derivatives Progesterone - immunology
We describe a simple method for estimating the association constant between an antibody and an antigen, based on a theoretical treatment of experimental dose-response data. We used this method to calculate the association constants of an anti-progesterone monoclonal antibody for native progesterone and for progesterone 11 alpha-hemisuccinate. These association constants provide a quantitative measure of the bridging-group recognition by the antibody.

Metrics

5 Record Views
3 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types
Domestic collaboration
Citation topics
1 Clinical & Life Sciences
1.159 Membrane Channels & Receptors
1.159.426 Bacteriorhodopsin
Web Of Science research areas
Medical Laboratory Technology
ESI research areas
Clinical Medicine

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: InCites

Details