Abstract
Lion's Mane (Hericium erinaceus) has historically been used as
traditional medicine in Asia and Europe for its potential benefits in
fighting infection and cancer. It has gained interest in the
neurodegenerative disease field because of its mechanisms of action;
these include anti-inflammation, neuroprotection, and promoting neurite
growth demonstrated in various cell and animal models. A very small,
double-blind, placebo-controlled trial in patients with mild cognitive
impairment showed a temporary improvement in cognitive function; this
finding has yet to be replicated. However, there have been no studies in
ALS cell or animal models or in humans with ALS. Lion's Mane appears
safe and inexpensive when consumed in powder or capsule, but one
anaphylactic case was reported after a patient consumed fresh Lion's
Mane mushroom. Currently, we do not have enough information to support
the use of Lion's Mane for treating ALS. We support further research in
ALS disease models and clinical trials to study its efficacy.
