ALSUntangled #75: Portable neuromodulation stimulator therapy

Laurel Officer; Carmel Armon; Paul Barkhaus; Morgan Beauchamp; Michael Benatar; Tulio Bertorini; Robert Bowser; Mark Bromberg; Andrew Brown; Olimpia Mihaela Carbunar; Gregory T Carter; Jesse Crayle; Keelie Denson; Eva Feldman; Timothy Fullam; Terry Heiman-Patterson; Carlayne Jackson; Sartaj Jhooty; Danelle Levinson; Xiaoyan Li; Alexandra Linares; Elise Mallon; Javier Mascias Cadavid; Christopher Mcdermott; Tasnim Mushannen; Lyle Ostrow; Ronak Patel; Gary Pattee; Dylan Ratner; Yuyao Sun; John Sladky; Paul Wicks; Richard Bedlack

ALSUntangled #75: Portable neuromodulation stimulator therapy

Journal article

Peer reviewed

ALSUntangled #75: Portable neuromodulation stimulator therapy

Laurel Officer, Carmel Armon, Paul Barkhaus, Morgan Beauchamp, Michael Benatar, Tulio Bertorini, Robert Bowser, Mark Bromberg, Andrew Brown, Olimpia Mihaela Carbunar, …

Amyotrophic lateral sclerosis and frontotemporal degeneration, p.1

2024-04-26

PMID: 38666601

Appears in Miller School of Medicine - Latest Publications

Abstract

neuromodulation

Electrical stimulation

PoNS™ Device

Spurred by patient interest, ALSUntangled herein examines the potential of the Portable Neuromodulation Stimulator (PoNS™) in treating amyotrophic lateral sclerosis (ALS). The PoNS™ device, FDA-approved for the treatment of gait deficits in adult patients with multiple sclerosis, utilizes translingual neurostimulation to stimulate trigeminal and facial nerves via the tongue, aiming to induce neuroplastic changes. While there are early, promising data for PoNS treatment to improve gait and balance in multiple sclerosis, stroke, and traumatic brain injury, no pre-clinical or clinical studies have been performed in ALS. Although reasonably safe, high costs and prescription requirements will limit PoNS accessibility. At this time, due to the lack of ALS-relevant data, we cannot endorse the use of PoNS as an ALS treatment.

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Details

Title: ALSUntangled #75: Portable neuromodulation stimulator therapy
Creators: Laurel Officer - San Antonio Military Medical Center
Carmel Armon - Department of Neurology, Shamir Medical Center, Tzrifin, Israel
Paul Barkhaus - Medical College of Wisconsin
Morgan Beauchamp - UNC Neuroscience Clinical Trials Unit, Chapel Hill, NC, USA
Michael Benatar - University of Miami
Tulio Bertorini - University of Tennessee Health Science Center
Robert Bowser - Barrow Neurological Institute
Mark Bromberg - University of Utah
Andrew Brown - University of Miami
Olimpia Mihaela Carbunar - University of Miami
Gregory T Carter - Washington State University Spokane
Jesse Crayle - Department of Neurology, Washington University, St. Louis, MO, USA
Keelie Denson - Houston Methodist
Eva Feldman - University of Michigan–Ann Arbor
Timothy Fullam - San Antonio Military Medical Center
Terry Heiman-Patterson - Department of Neurology, Temple Health, Philadelphia, PA, USA
Carlayne Jackson - Department of Neurology, UT Health San Antonio, San Antonio, Texas, USA
Sartaj Jhooty - University of North Carolina at Chapel Hill
Danelle Levinson - Duke University
Xiaoyan Li - Duke University
Alexandra Linares - Duke University
Elise Mallon - Duke University
Javier Mascias Cadavid - Hospital La Paz Institute for Health Research
Christopher Mcdermott - University of Sheffield
Tasnim Mushannen - Duke University
Lyle Ostrow - Department of Neurology, Temple Health, Philadelphia, PA, USA
Ronak Patel - San Antonio Military Medical Center
Gary Pattee - University of Nebraska Medical Center
Dylan Ratner - University of New Orleans
Yuyao Sun - University of Kentucky
John Sladky - San Antonio Military Medical Center
Paul Wicks - Independent Consultant, Lichfield, England, UK
Richard Bedlack - Duke University
Publication Details: Amyotrophic lateral sclerosis and frontotemporal degeneration, p.1
Academic Unit: Miller School of Medicine; UMMG Department of Neurology; UMMG Dept of Neurology - Neuromuscular Disorders Div
Language: English
Resource Type: Journal article
PMID: 38666601
Record Identifier: 991032028585602976