APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO): Design and Rationale

Barry I Freedman; Marva M Moxey-Mims; Amir A Alexander; Brad C Astor; Kelly A Birdwell; Donald W Bowden; Gordon Bowen; Jonathan Bromberg; Timothy E Craven; Darshana M Dadhania; Jasmin Divers; Mona D Doshi; Elling Eidbo; Alessia Fornoni; Michael D Gautreaux; Rasheed A Gbadegesin; Patrick O Gee; Giselle Guerra; Chi-yuan Hsu; Ana S Iltis; Nichole Jefferson; Bruce A Julian; David K Klassen; Patrick P Koty; Carl D Langefeld; Krista L Lentine; Lijun Ma; Roslyn B Mannon; Madhav C Menon; Sumit Mohan; J. Brian Moore; Barbara Murphy; Kenneth A Newell; Jonah Odim; Mariella Ortigosa-Goggins; Nicholette D Palmer; Meyeon Park; Afshin Parsa; Stephen O Pastan; Emilio D Poggio; Nishadi Rajapakse; Amber M Reeves-Daniel; Sylvia E Rosas; Laurie P Russell; Deirdre Sawinski; S. Carrie Smith; Mitzie Spainhour; Robert J Stratta; Matthew R Weir; David M Reboussin; Paul L Kimmel; Daniel C Brennan

doi:10.1016/j.ekir.2019.11.022

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APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO): Design and Rationale

Journal article

Open access

Peer reviewed

APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO): Design and Rationale

Barry I Freedman, Marva M Moxey-Mims, Amir A Alexander, Brad C Astor, Kelly A Birdwell, Donald W Bowden, Gordon Bowen, Jonathan Bromberg, Timothy E Craven, Darshana M Dadhania, …

Kidney international reports, Vol.5(3), pp.278-288

2020-03

DOI: https://doi.org/10.1016/j.ekir.2019.11.022

PMCID: PMC7056919

PMID: 32154449

Abstract

African Americans

chronic kidney disease

APOL1

graft failure

outcomes

kidney transplantation

Much of the higher risk for end-stage kidney disease (ESKD) in African American individuals relates to ancestry-specific variation in the apolipoprotein L1 gene (APOL1). Relative to kidneys from European American deceased-donors, kidneys from African American deceased-donors have shorter allograft survival and African American living-kidney donors more often develop ESKD. The National Institutes of Health (NIH)–sponsored APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) is prospectively assessing kidney allograft survival from donors with recent African ancestry based on donor and recipient APOL1 genotypes. APOLLO will evaluate outcomes from 2614 deceased kidney donor-recipient pairs, as well as additional living-kidney donor-recipient pairs and unpaired deceased-donor kidneys. The United Network for Organ Sharing (UNOS), Association of Organ Procurement Organizations, American Society of Transplantation, American Society for Histocompatibility and Immunogenetics, and nearly all U.S. kidney transplant programs, organ procurement organizations (OPOs), and histocompatibility laboratories are participating in this observational study. APOLLO employs a central institutional review board (cIRB) and maintains voluntary partnerships with OPOs and histocompatibility laboratories. A Community Advisory Council composed of African American individuals with a personal or family history of kidney disease has advised the NIH Project Office and Steering Committee since inception. UNOS is providing data for outcome analyses. This article describes unique aspects of the protocol, design, and performance of APOLLO. Results will guide use of APOL1 genotypic data to improve the assessment of quality in deceased-donor kidneys and could increase numbers of transplanted kidneys, reduce rates of discard, and improve the safety of living-kidney donation. [Display omitted]

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.55 Urology & Nephrology - General; 1.55.352 Chronic Kidney Disease
Web Of Science research areas: Urology & Nephrology
ESI research areas: Clinical Medicine

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Title: APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO): Design and Rationale
Creators: Barry I Freedman - Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Marva M Moxey-Mims - Division of Nephrology, Children's National Health System, Washington, DC, USA
Amir A Alexander - Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Brad C Astor - Department of Medicine, Division of Nephrology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Kelly A Birdwell - Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University, Nashville, Tennessee, USA
Donald W Bowden - Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Gordon Bowen - Lifebanc, Cleveland, Ohio, USA
Jonathan Bromberg - Department of Surgery, Division of Transplantation, University of Maryland School of Medicine, Baltimore, Maryland, USA
Timothy E Craven - Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Darshana M Dadhania - Division of Nephrology, Weill Cornell Medicine, New York, New York, USA
Jasmin Divers - Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Mona D Doshi - Division of Nephrology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
Elling Eidbo - Association of Organ Procurement Organizations, Vienna, Virginia, USA
Alessia Fornoni - Katz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Drug Discovery Center, University of Miami Miller School of Medicine, Miami, Florida, USA
Michael D Gautreaux - Human Leukocyte Antigen/Immunogenetics and Immunodiagnostics Laboratories, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Rasheed A Gbadegesin - Department of Pediatrics, Division of Nephrology, Duke University School of Medicine, Durham, North Carolina, USA
Patrick O Gee - APOLLO Community Advisory Council, Cleveland Clinic, Cleveland, Ohio, USA
Giselle Guerra - Katz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Drug Discovery Center, University of Miami Miller School of Medicine, Miami, Florida, USA
Chi-yuan Hsu - Department of Medicine, Division of Nephrology, University of California, San Francisco, San Francisco, California, USA
Ana S Iltis - Center for Bioethics, Health and Society, Department of Philosophy, Wake Forest University, Winston-Salem, North Carolina, USA
Nichole Jefferson - APOLLO Steering Committee, APOLLO Community Advisory Council, Dallas, Texas, USA
Bruce A Julian - Department of Medicine, Division of Nephrology, University of Alabama School of Medicine in Birmingham, Birmingham, Alabama, USA
David K Klassen - United Network for Organ Sharing, Office of the Chief Medical Officer, Richmond, Virginia, USA
Patrick P Koty - Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Carl D Langefeld - Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Krista L Lentine - Department of Medicine, Center for Abdominal Transplantation, Saint Louis University School of Medicine, St. Louis, Missouri, USA
Lijun Ma - Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Roslyn B Mannon - Department of Medicine, Division of Nephrology, University of Alabama School of Medicine in Birmingham, Birmingham, Alabama, USA
Madhav C Menon - Department of Nephrology, Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Sumit Mohan - Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, New York, USA
J. Brian Moore - Institutional Review Board, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Barbara Murphy - Department of Nephrology, Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Kenneth A Newell - Department of Surgery, Division of Transplantation, Emory University School of Medicine, Atlanta, Georgia, USA
Jonah Odim - Transplantation Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Mariella Ortigosa-Goggins - Katz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Drug Discovery Center, University of Miami Miller School of Medicine, Miami, Florida, USA
Nicholette D Palmer - Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Meyeon Park - Department of Medicine, Division of Nephrology, University of California, San Francisco, San Francisco, California, USA
Afshin Parsa - Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
Stephen O Pastan - Department of Medicine, Renal Division, Emory University School of Medicine, Atlanta, Georgia, USA
Emilio D Poggio - Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA
Nishadi Rajapakse - National Institutes of Health, National Institute on Minority Health and Health Disparities, Division of Scientific Programs, Bethesda, Maryland, USA
Amber M Reeves-Daniel - Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Sylvia E Rosas - Kidney and Hypertension Unit, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, USA
Laurie P Russell - Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Deirdre Sawinski - Renal Electrolyte and Hypertension Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
S. Carrie Smith - Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Mitzie Spainhour - Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Robert J Stratta - Department of Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Matthew R Weir - Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland, USA
David M Reboussin - Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Paul L Kimmel - Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
Daniel C Brennan - Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Publication Details: Kidney international reports, Vol.5(3), pp.278-288
Publisher: Elsevier Inc
Academic Unit: Miller School of Medicine; Peggy and Harold Katz Family Drug Discovery Center; UMMG Dept of Medicine - Nephrology & Hypertension Div
Language: English
Resource Type: Journal article
PMID: 32154449
PMCID: PMC7056919
Record Identifier: 991031577465302976