Abstract
Introduction: The prognostic value of Positron Emission Tomography (PET) Myocardial Perfusion Imaging (MPI) is well established; however, it has not been extensively studied in subjects with diabetes mellitus (DM). We aimed to assess the prognostic value of PET MPI in subjects with and without DM. Methods: We studied 6037subjects (mean age 63±13 years, 47% women, 27% with DM, mean ejection fraction 60±16%, 33% with known coronary disease) who underwent a clinically indicated rest/stress Rubidium-82 PET MPI at 4 centers. Cardiac death (n=169) was evaluated at a mean follow-up of 2.5 ± 1.5 years. We used Cox proportional hazards models and risk reclassification measures stratified according to reported DM status. Bracco and Astellas provided initial funding for the PET registry. The current analysis is independently performed by the PET registry investigators. Results: Subjects with DM had a higher risk of cardiac death [hazard ratio (HR) (95% CI): 2.6 (1.9-3.5)] compared to those without DM. In multivariab...