Abstract
Introduction: Plasma LDL-c, HDL-c and triglycerides are traditionally used to assess dyslipidemic burden and subsequent cardiovascular disease (CVD) risk management. In this study we whether detailed assessment across spectrum of multiple lipoproteins subclasses, distinguished by their physiochemical properties, can guide atherosclerotic risk assessment as measured by coronary artery calcification (CAC) burden in a high CVD risk population. Methods: The Baptist Employee Healthy Heart Study (BEHHS) is an ongoing lifestyle intervention study examining the effects of web-based interventions on reducing CVD risk in individuals with metabolic syndrome (MS) and type II DM. Cardio IQ™ Ion Mobility lipoprotein fractionation was utilized for advanced lipid subclass measurement resulting direct quantification of particles in each lipoprotein subclass fraction. Results: The population consisted of 171 participants (74% women, 49% Hispanic, mean age: 52 ± 9 years) undergoing CAC testing. The table demonstrates a significant trend of a lower LDL particle size concentration with increasing CAC score. Conversely, those with CAC=0 were more likely to have higher concentration of large LDL, small IDL, small & large HDL respectively. In our study 104 (60%) had LDL pattern B (LDL Peak Size Conclusions: Several lipoprotein subclasses by ion mobility analysis, particularly smaller LDL peak particle diameter (LDL pattern B) were related to increased burden of coronary atherosclerosis independent of standard lipoprotein analysis in high risk individuals with MS/DM.