Abstract
Byline: Jill H Esquivel, Univ of Virginia, Charlottesville, VA; Jeongok G Logan, Univ of Virginia, Charlottesvle, VA; Daniela Sotres-Alvarez, UNC Chapel Hill, CHAPEL HILL, NC; Sonia Ponce, UNIVERSITY OF CALIFORNIA SAN DIEGO, La Jolla, CA; Matthew A Allison, Univ of California San Diego, La Jolla, CA; Barry E Hurwitz, UNIVERSITY OF MIAMI, Miami, FL; Robert Kaplan, Albert Einstein College of Medicine, Bronx, NY; Carmen R Isasi, ALBERT EINSTEIN COLLEGE MEDICINE, Bronx, NY; Jainwen Cai, Univ of North Carolina, Chapel Hill, NC; Martha L Daviglus, UNIVERSITY ILLINOIS CHICAGO, Chicago, IL; Mayank M Kansal, Univ of Illinois at Chicago, Chicago, IL; Carlos J Rodriguez, Albert Einstein Sch of Medicine, Bronx, NY Introduction: Obesity is an epidemiologic challenge and a key risk factor for heart failure (HF). Pre-heart failure (pre-HF) has been recognized as an important entity to prevent progression to clinical HF. Defining the long-term effect of obesity on pre-HF is essential for understanding of HF risk and prevention. Purpose: To determine the prospective association of obesity on the incidence of pre-HF (defined as the presence of abnormal cardiac structure or function among persons without clinical HF). Methods: Data from 1580 individuals without HF and with anthropometric data from the population-based Echocardiographic-Study of Latinos were included. Pre-HF was defined as: 1) Systolic dysfunction - LV ejection fraction (LVEF) < 50% and global longitudinal strain (GLS) <15%; 2) LV diastolic dysfunction - E/e' >10 and left atrial volume index (LAVI) >34 mL/m2; or 3) LV remodeling - LV mass index (LVMI)> 115gm/m2, >95gm/m2 (male and female, respectively) and relative wall thickness (RWT) >0.42. Anthropometric data were: (body mass index {BMI}, waist circumference {WC}, waist-to-hip ratio {WHR}, fat mass {FM) and free fat mass {FFM}). Echocardiographic and anthropometric data were collected twice, on average 4.3 years apart, and analyzed using survey-weighted multivariable-adjusted regression models. Incident pre-HF was determined among participants Results: Mean age of 56 (42-74) years and 1048 (66%) were female. Baseline mean BMI was 29.9 kgm2, FM kg 28.3, FFM kg 50.1, WC 99.7cm, and WHR 0.94. Baseline BMI, FFM, FM, WC and WHR were significantly higher in individuals with prevalent pre-HF (all p<0.007). Longitudinal data showed that WC and WHR were associated with greater probability of incident pre-HF (WC and WHR p<0.0006. Regression models showed BMI, WC, WHR and FFM were associated with increased odds of incident Pre-HF (Table 1).
