Abstract
Introduction:
First-pass reperfusion effect (FPE) appears superior to multiple device passes in achieving good functional recovery in endovascular thrombectomy (EVT). It is unclear if this represents an epiphenomenon or a true independent effect. Historically, earlier treatment has been associated with improved functional recovery. We analyzed how these two variables interact using the STRATIS registry data.
Methods:
The STRATIS registry prospectively enrolled large vessel occlusion, stroke patients, treated with Solitaire and/or Mindframe Capture low profile revascularization devices within 8 hours of symptom onset. Reperfusion was assessed by an independent core lab.
Results:
A total of 984 patients were enrolled (mean age 67.8 +/- 14.7 years, 54.2% male, median NIHSS 17). Mean time from stroke onset to groin puncture was 226.4+/- 100.0 minutes. At 90 days, functional recovery (mRS 0-2) was achieved in 56.5%. Core lab assessment was performed in 824 cases with a mTICI2b/3 rate of 87.9%. Every 60-minute delay to treatment was associated with less functional recovery cOR 0.79 (95% CI, 0.68 - 0.93). In patients with first-pass effect reperfusion (FPE), delay to treatment did not affect functional recovery FPE-mTICI 2b cOR 1.03 (95% CI, 0.83 - 1.28) or FPE-mTICI 2c/3 cOR 0.96 (95% CI, 0.84 - 1.11). Poor reperfusion (FPE-mTICI <2b) maintained a negative relationship between functional recovery and delay to treatment cOR 0.76 (95% CI, 0.66 - 0.88).
Conclusion:
First pass effect may reduce the impact of delays to treatment compared to historical data. Further studies to determine the mechanism of this effect are required.