Age at Onset in Two Common Neurodegenerative Diseases Is Genetically Controlled

Yi-Ju Li; William K Scott; Dale J Hedges; Fengyu Zhang; P. Craig Gaskell; Martha A Nance; Ray L Watts; Jean P Hubble; William C Koller; Rajesh Pahwa; Matthew B Stern; Bradley C Hiner; Joseph Jankovic; Fred H Allen, Jr; Christopher G Goetz; Frank Mastaglia; Jeffrey M Stajich; Rachel A Gibson; Lefkos T Middleton; Ann M Saunders; Burton L Scott; Gary W Small; Kristin K Nicodemus; Allison D Reed; Donald E Schmechel; Kathleen A Welsh-Bohmer; P. Michael Conneally; Allen D Roses; John R Gilbert; Jeffery M Vance; Jonathan L Haines; Margaret A Pericak-Vance

doi:10.1086/339815

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Age at Onset in Two Common Neurodegenerative Diseases Is Genetically Controlled

Journal article

Open access

Peer reviewed

Age at Onset in Two Common Neurodegenerative Diseases Is Genetically Controlled

Yi-Ju Li, William K Scott, Dale J Hedges, Fengyu Zhang, P. Craig Gaskell, Martha A Nance, Ray L Watts, Jean P Hubble, William C Koller, Rajesh Pahwa, …

American journal of human genetics, Vol.70(4), pp.985-993

2002-04

DOI: https://doi.org/10.1086/339815

PMCID: PMC379130

PMID: 11875758

Abstract

To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n =449 ) and Parkinson disease (PD; n =174 ). Heritabilities between 40%–60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10 was identified independently in both the AD and PD data sets. Subsequent unified analyses of these regions identified a single peak on chromosome 10q between D10S1239 and D10S1237, with a maximum LOD score of 2.62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases.

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.57 Alzheimer's Disease
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics

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Title: Age at Onset in Two Common Neurodegenerative Diseases Is Genetically Controlled
Creators: Yi-Ju Li - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
William K Scott - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Dale J Hedges - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Fengyu Zhang - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
P. Craig Gaskell - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Martha A Nance - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Ray L Watts - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Jean P Hubble - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
William C Koller - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Rajesh Pahwa - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Matthew B Stern - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Bradley C Hiner - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Joseph Jankovic - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Fred H Allen, Jr - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Christopher G Goetz - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Frank Mastaglia - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Jeffrey M Stajich - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Rachel A Gibson - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Lefkos T Middleton - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Ann M Saunders - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Burton L Scott - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Gary W Small - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Kristin K Nicodemus - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Allison D Reed - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Donald E Schmechel - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Kathleen A Welsh-Bohmer - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
P. Michael Conneally - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Allen D Roses - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
John R Gilbert - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Jeffery M Vance - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Jonathan L Haines - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Margaret A Pericak-Vance - Departments of Medicine and Psychiatry and Center for Human Genetics, Duke University Medical Center, Durham, NC
Publication Details: American journal of human genetics, Vol.70(4), pp.985-993
Publisher: The American Society of Human Genetics
Academic Unit: Miller School of Medicine; John P. Hussman Institute for Human Genomics; UMMG Dept of Human Genetics - Clinical and Translational Genetics; UMMG Dept of Human Genetics (Dr. John T. Macdonald Foundation)
Language: English
Resource Type: Journal article
PMID: 11875758
PMCID: PMC379130
Record Identifier: 991031559445702976