Age-related shift in brain region activity during successful memory performance

E.A Hazlett; M.S Buchsbaum; R.C Mohs; J Spiegel–Cohen; T.-C Wei; R Azueta; M.M Haznedar; M.B Singer; L Shihabuddin; C Luu–Hsia; P.D Harvey

doi:10.1016/S0197-4580(98)00075-X

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Age-related shift in brain region activity during successful memory performance

Journal article

Peer reviewed

Age-related shift in brain region activity during successful memory performance

E.A Hazlett, M.S Buchsbaum, R.C Mohs, J Spiegel–Cohen, T.-C Wei, R Azueta, M.M Haznedar, M.B Singer, L Shihabuddin, C Luu–Hsia, …

Neurobiology of aging, Vol.19(5), pp.437-445

1998

DOI: https://doi.org/10.1016/S0197-4580(98)00075-X

PMID: 9880046

Abstract

Verbal memory

Regional glucose metabolism

Frontal lobe

Normal aging

Positron emission tomography

Coregistered positron emission tomography (PET)/magnetic resonance imaging (MRI) was used to characterize brain function in 70 volunteers, aged 20–87 years, during a verbal memory task. Frontal activity showed an age-related decline that remained significant after statistical control for sulcal atrophy. Analyses of young and old subgroups matched for memory scores revealed that young good performers activated frontal regions, whereas old good performers relied on occipital regions. Although activating different cortical regions, good performers of all ages used the same cognitive strategy—semantic clustering. Age-related functional change may reflect dynamic re-allocation in a network of brain areas, not merely anatomically fixed neuronal loss or diminished capacity to perform.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.60 Dementia
Web Of Science research areas: Geriatrics & Gerontology; Neurosciences
ESI research areas: Neuroscience & Behavior

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Details

Title: Age-related shift in brain region activity during successful memory performance
Creators: E.A Hazlett - Neuroscience PET Laboratory, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA
M.S Buchsbaum - Neuroscience PET Laboratory, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA
R.C Mohs - Psychiatry Service, Department of Veterans Affairs Medical Center, 130 W. Kingsbridge Road, Bronx, NY 10468, USA
J Spiegel–Cohen - Neuroscience PET Laboratory, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA
T.-C Wei - Neuroscience PET Laboratory, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA
R Azueta - Neuroscience PET Laboratory, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA
M.M Haznedar - Neuroscience PET Laboratory, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA
M.B Singer - Neuroscience PET Laboratory, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA
L Shihabuddin - Psychiatry Service, Department of Veterans Affairs Medical Center, 130 W. Kingsbridge Road, Bronx, NY 10468, USA
C Luu–Hsia - Neuroscience PET Laboratory, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA
P.D Harvey - Neuroscience PET Laboratory, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA
Publication Details: Neurobiology of aging, Vol.19(5), pp.437-445
Publisher: Elsevier Inc
Academic Unit: Miller School of Medicine; UMMG Dept of Psychiatry & Behavioral Sciences
Language: English
Resource Type: Journal article
PMID: 9880046
Record Identifier: 991031561809202976