Alu elements and hominid phylogenetics

Abdel-Halim Salem; David A Ray; Jinchuan Xing; Pauline A Callinan; Jeremy S Myers; Dale J Hedges; Randall K Garber; David J Witherspoon; Lynn B Jorde; Mark A Batzer

doi:10.1073/pnas.2133766100

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Alu elements and hominid phylogenetics

Abdel-Halim Salem, David A Ray, Jinchuan Xing, Pauline A Callinan, Jeremy S Myers, Dale J Hedges, Randall K Garber, David J Witherspoon, Lynn B Jorde and Mark A Batzer

Proceedings of the National Academy of Sciences - PNAS, Vol.100(22), pp.12787-12791

2003-10-28

DOI: https://doi.org/10.1073/pnas.2133766100

PMCID: PMC240696

PMID: 14561894

Abstract

Biological Sciences

trichotomy

mobile elements

primates

short interspersed elements

Alu elements have inserted in primate genomes throughout the evolution of the order. One particular Alu lineage (Ye) began amplifying relatively early in hominid evolution and continued propagating at a low level as many of its members are found in a variety of hominid genomes. This study represents the first conclusive application of short interspersed elements, which are considered nearly homoplasy-free, to elucidate the phylogeny of hominids. Phylogenetic analysis of Alu Ye5 elements and elements from several other subfamilies reveals high levels of support for monophyly of Hominidae, tribe Hominini and subtribe Hominina. Here we present the strongest evidence reported to date for a sister relationship between humans and chimpanzees while clearly distinguishing the chimpanzee and human lineages.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.54 Molecular & Cell Biology - Genetics; 1.54.1122 Transposable Elements
Web Of Science research areas: Biochemistry & Molecular Biology
ESI research areas: Molecular Biology & Genetics

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Details

Title: Alu elements and hominid phylogenetics
Creators: Abdel-Halim Salem - Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803
David A Ray - Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803
Jinchuan Xing - Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803
Pauline A Callinan - Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803
Jeremy S Myers - Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803
Dale J Hedges - Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803
Randall K Garber - Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803
David J Witherspoon - Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803
Lynn B Jorde - Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803
Mark A Batzer - Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.100(22), pp.12787-12791
Publisher: National Academy of Sciences
Academic Unit: UMMG Dept of Human Genetics (Dr. John T. Macdonald Foundation)
Language: English
Resource Type: Journal article
PMID: 14561894
PMCID: PMC240696
Record Identifier: 991031559928302976