Abstract
Objective: To find any correlation between microscopic angiogenesis grading system (MAGS) score and Gleason score and serum prostate specific antigen (S.PSA) in carcinoma of prostate.
Study design: Examination of 30 patients with prostatic carcinoma compared with an age matched control group of 30 patients having histopathologically proven benign prostatic Hyperplasia. The Preoperative serum PSA level was determined in all patients. Histopathological examination for MAGS score was done in all patients and Gleason scoring was done for cases of prostatic carcinoma.
Result: MAGS score had a definite correlation with Gleason score (Correlation coefficient,
). Studying the relationship between MAGS score and S.PSA, a statistically significant difference is found between S.PSA levels in study and control groups, and in the three MAGS score groups namely 21-30, 31-40 and 41-50.
Conclusion: Gleason score and MAGS score are well related to each other. As tumor becomes more poorly differentiated with rising Gleason score, it would also have increased number of capillaries and higher grade endothelial cytology leading to a higher MAGS score.